What Are the Major Depressive Disorder Symptoms? Learn about key signs of major depressive disorder, including persistent sadness, fatigue, and changes in appetite, and how early intervention with therapy or psychiatric care can help. Our customer service team is available seven days a week from 7:15 a.m. to 6:15 p.m. Visit www.hupcfl.com or call +1 800 457 4573. https://hupcfl.com/what-are-the-major-depressive-disorder-symptoms/