Current genome-wide association studies (GWAS) have high power to detect intermediate frequency SNPs making modest contributions to complex disease. but they are underpowered to detect rare alleles of large effect (RALE). This has led to speculation that the bulk of variation for most complex diseases is due to RALE. One concern with existing models of RALE is that they do not make ex... https://foldlyers.shop/product-category/modem-router/